Diagnostic Utility

Anti-actin antibodies are especially useful in the work-up of spindle cell dermal neoplasms. As they are relatively sensitive and specific markers for muscular differentiation, a positive stain points the diagnosis in this direction (Table 1). A negative result helps to exclude muscular tumors. Actin is detected in virtually all cutaneous leiomyomas (Fig. 3) (20). Actin expression is thought to be more sensitive, though possibly less specific than desmin in identifying

Glomus Tumor Markers
Fig. 2. Smooth muscle actin is present in cells surrounding blood vessel walls within the dermis in this vascular neoplasm.

Table 1

Essentials of Anti-Actin Antibodies*

Table 1

Essentials of Anti-Actin Antibodies*

Smooth muscle tumors

Sensitivity

Leiomyoma

100%

Glomus tumor

100%

Leiomyosarcoma

70-100%

Other tumors known to express actin

0 0

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