Diagnostic Utility

Anti-borrelia burgdorferi antibodies can be useful in making a diagnosis of erythema chronicum migrans (associated with Lyme disease). European authors have also found the antibody helpful in confirming the etiologies in cases of morphea, lymphocytoma, and lichen sclerosis and acrodermatitis chronica atrophicans (16,18). American authors have not shared this experience.

Anti-Treponema pallidum antibodies used with a standard avidin-biotin-immunoperoxidase technique have been shown to be more sensitive at detecting organisms within skin specimens than darkfield examinations and other techniques (17,19).

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