There is only limited utility for anti-LCA antibodies in diagnostic dermatopathology. In the vast majority of cases, it is possible to identify cells as being hematopoietic without resorting to antibody

Fig. 1. Leukocyte common antigen is strongly expressed by the vast majority of hematopoietic cells.

labeling. However, in the rare cases when it is difficult to make this distinction, this antibody may be useful. It should be noted that in some types of large cell lymphomas and plasma cell proliferations, LCA might not be expressed by neoplastic leukocytes, further diminishing the utility of this marker.

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