Combined Agents

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Conjugated equine Prempro estrogens/medroxy-

progesterone acetate Premphase

Conjugated equine Estratest estrogens/methyl-

testosterone

Estradiol/norgestimate Prefest

Estradiol/norethindrone Activella Ethinyl estradiol/ FemHRT

norethindrone

0.3/1.5; 0.45/1.5; 0.625/2.5; 0.625/5 (mg/mg) 0.625/0 x 21days, then 0.625/5 x 7 days (mg/mg) 1.25/2.5 (mg/mg)

Reprinted with permission from: Moghadam KK, Williams DB. Advances in menopausal hormonal delivery systems: A comparative review. Am J Drug Deliv 2005; 3:7-16.

many women, resulting in night sweats, multiple episodes of awakening, and overall nonrestful sleep. The resulting decreased sleep efficiency caused by hot flashes may explain the associated chronic fatigue and irritability from which many menopausal women suffer. The most effective treatment for hot flushes is estrogen, which can be given through a variety of regimens, that are described below and listed in Tables

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