Capsazepine attenuates interstitial oedema and neutrophil infiltration in the rat pancreas following infusion of the secretagogue cerulein .
Functional TRPV1 is expressed in keratinocytes, hair follicles, sebocytes and sweat gland cells [151, 152]. In organ cultures, activation by capsaicin of
TRPV1 results in premature hair follicle regression and apoptosis . This finding confers a therapeutic potential for TRPV1 antagonists in the treatment of alopecia. In prurigo nodularis, enhanced TRPV1 expression was found that normalized during capsaicin treatment .
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