Acute Pancreatitis

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Capsazepine attenuates interstitial oedema and neutrophil infiltration in the rat pancreas following infusion of the secretagogue cerulein [150].

HUMAN HAIR GROWTH CONTROL (ALOPECIA) AND DERMATOLOGIC DISORDERS

Functional TRPV1 is expressed in keratinocytes, hair follicles, sebocytes and sweat gland cells [151, 152]. In organ cultures, activation by capsaicin of

TRPV1 results in premature hair follicle regression and apoptosis [153]. This finding confers a therapeutic potential for TRPV1 antagonists in the treatment of alopecia. In prurigo nodularis, enhanced TRPV1 expression was found that normalized during capsaicin treatment [154].

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