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In addition to the imidazole-based compounds detailed earlier, more recently the Schering-Plough group reported on several new series of H3 antagonists including oximes (47) [121], benzimidazoles (48) [122], benzimidazolones (49) [123], and indoles (50) [124]. All of the compounds shown have K;s of less than 10 nM in guinea-pig brain.

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