Nuclear Overhauser Effects

Nuclear Overhauser effects (NOEs) cause changes in the intensity of NMR signals by through-space dipole-dipole interactions [36]. The magnitude of an observed NOE between two magnetic nuclei gives useful information on the distances between them. The observed NOE is also related to Brownian rotational tumbling, with small, rapidly tumbling molecules giving positive NOEs and a maximum relative signal strength of 50%, and large, slowly tumbling molecules giving negative NOEs with a maximum relative signal decrease of 100%.

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