Several types of CB2 agonists with monocyclic core structures have been reported, these compounds being structurally distinct from other series of CB2 agonists. Tetrazine derivative (377) exhibited 90-fold selectivity for CB2 and 2-imino-1,3-thiazolidine (378) showed more than 500-fold selectivity [234, 235]. A pyridone analogue (379) of a bicyclic CB1 agonist, CP 47,497 (l92) showed CB2 selective activity [Ki(CB1) = 973 nM, Ki(CB2) = 56 nM)] [236], though the origin of the selectivity was unclear. The pyridine derivatives such as (380) were disclosed by Glaxo; (380) was more than 100 times selective for CB2 over CB1 receptors [237].


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