n-C6H13 Me Me
Classical/non-classical hybrid cannabinoids, such as (197) and (198), have been described by Tius et al. [137, 140]. In these compounds, a southern aliphatic hydroxyl group was added to the classical cannabinoid template. Addition of a C-6a hydroxyethyl substituent resulted in a loss of binding affinity, while the introduction of C-6b hydroxyethyl or hydroxypropyl groups resulted in increased affinity compared to the corresponding ethyl or propyl analogues.
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