Oxytocin Antagonists as Potential Therapeutic Agents for the Treatment of Preterm Labour

MICHAEL J. ALLEN,1 DAVID G.H. LIVERMORE1 and JACQUELINE E. MORDAUNT2

1GlaxoSmithKline, New Frontiers Science Park (North), Third Avenue, Harlow, Essex, CM19 5AW, UK

2GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK

INTRODUCTION 332

EPIDEMIOLOGY AND THE IMPACT OF PRETERM LABOUR 332

THE ANATOMY OF THE UTERUS 333

TREATMENT OF PRETERM LABOUR 333

The Role of Oxytocin in Labour 334

Regulation of Oxytocin during Labour 334

Regulation of the Oxytocin Receptor 335

Experiences with Oxytocin Antagonists 335

Selective OT or Mixed OT/V1A Blockade? 336

Extra Uterine Roles of Oxytocin 337

0 0

Post a comment