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Iodinated capsaicinoids are easily available by synthesis [68, 73] and can function as potent TRPV1 antagonists in in vitro functional assays. On the other hand, little is known about their activity in vivo, or their metabolic stability and bioavailability. Since capsaicin itself is poorly absorbed after oral ingestion or from skin, and then is rapidly metabolized [1], these issues are of great relevance for further pharmaceutical development.

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