Receptorbased Screening

screening concerns development and evaluation, only recently have examples emerged where receptor-based screening was used purely in application. Muegge and Enyedy [70] recently reviewed virtual screening for kinase targets, discussing the many pitfalls and areas of concern. Receptor-based virtual screening can be broken down into several distinct stages; compound database and receptor preparation, protein-ligand docking, post-docking analysis and finally compound prioritization. Recent developments have centred upon docking and scoring, but it should be stressed that each stage is crucial to overall performance and so an overview of each will now be presented.

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