The Hydrophobic Chain

A variety of long-chain hydrocarbons have been found to be tolerated in this position as well as the parent hydrocarbon. In general, a minimum of one double bond located near or at the mid-point of the carbon chain is required for activity. In addition, the double bond must be cis configured (Table 6.1) [33].


A wide range of groups are tolerated in this position including esters, amides, thioesters, ureas, acyl hydrazines and carbamates exhibiting a wide range of potencies and microsomal stabilities (Table 6.2) [24, 33-36].

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