The Polar Head Group

The head group has been extensively studied and a diverse range of groups are tolerated including aliphatic, cyclic, aromatic and heteroaromatic groups [33, 34, 37]. In general, the presence of a polar head group is favoured but not essential. The presence of aromatic/heteroaromatic moieties is well tolerated; in addition, bulky groups can also be accommodated (Table 6.3).

The furan derivative (23) has been tested in vivo in tests of motor activity (open-field test) and antinociception (hot-plate test) as well as its capacity to enhance the hypokinetic and/or analgesic actions of subeffective doses of

Table 6.2 SAR OF THE CARBOXAMIDE/CARBOXYLATE GROUP

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