Therapeutic Applications Of Cannabinoid Agonists

Standardised preparations of cannabinoid agonists are available for therapeutic use in some countries [238]. Dronabinol (Marinolâ„¢), an oral preparation of A9-THC (67), is used clinically as an appetite stimulant in AIDS patients and an antiemetic in cancer chemotherapy. A synthetic analogue of (67), nabilone (Cesametâ„¢), (381), is also used to suppress nausea and vomiting in cancer chemotherapy.

There have been a number of studies to evaluate the therapeutic effect of cannabinoids against spastic disorders, including multiple sclerosis and spinal cord injury. For example, a randomised placebo-controlled trial in more than

600 multiple sclerosis patients with oral cannabis extract or (67) was performed and an objective improvement in mobility was observed in the study [239].

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