In diabetic rats, TRPV1 is enhanced on myelinated fibres and is hyperphos-phorylated by PKC . In accordance with these findings, anti-TRPV1 antiserum was shown to ameliorate pain in a murine model of diabetic neuropathy . In humans, the density of TRPV1-positive nerve fibres is increased in women with chronic breast pain  and with vulvodynia . Disruption of TRPV1 gene causes attenuation of bone cancer pain in mice . Pharmacological blockade of TRPV1 by agonists relieved pain in AIDS patients .
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