Lipid Protein Interactions

Effects of lipids on the function of membrane proteins can be described either at the microscopic or at the macroscopic level. An explanation at the microscopic level is a "molecular" level interpretation in terms of interactions such as hydrogen bonding, charge-charge interactions, and van der Waals interactions. An explanation at the macroscopic level involves properties of the whole membrane such as membrane viscosity, membrane pressure, and curvature stress. In some cases it is clear that an interpretation at the microscopic level is the most appropriate. In others, explanations at both the microscopic and macroscopic levels are possible, although even in these cases, an explanation at the microscopic level is often the most attractive when a crystal structure for the protein is available.

Fig. 6.6. The structure ofthe phosphatidylcholine binding site on LukF. Only the phosphorylcholine head-groupwasresolved inthecrystal structure, shown in space fill format. Residues surrounding the headgroup binding site are shown in ball-and-stick format(PDBfile3LKF)

' Phosphate Choline

Fig. 6.6. The structure ofthe phosphatidylcholine binding site on LukF. Only the phosphorylcholine head-groupwasresolved inthecrystal structure, shown in space fill format. Residues surrounding the headgroup binding site are shown in ball-and-stick format(PDBfile3LKF)

' Phosphate Choline

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