Isoniazid And Iproniazid

Metabolism Isoniazid

Isoniazid and iproniazid are chemically similar drugs having different pharmacological effects they may both cause liver damage after therapeutic doses are given. Isoniazid is still widely used for the treatment of tuberculosis, but iproniazid is now rarely used as an antidepressant. The major routes of metabolism for isoniazid are acetylation to give acetylisoniazid, followed by hydrolysis to yield isonicotinic acid FIGURE 7.15 Metabolism of isoniazid. The acetylhydrazine released by the...

Haloalkanes And Alkenes

Imagens Metabolismo

A variety of halogenated alkanes and alkenes such as hexachlorobutadiene, chlorotrifluoroethylene, tetrafluoroethylene and trichloroethylene figure 7.18 are nephrotoxic. Studies have shown that metabolic activation is necessary for toxicity, but this does not involve cytochromes P-450. Thus, hexachlorobutadiene HCBD is a potent nephrotoxin in a variety of mammalian species, and the kidney is the major target. FIGURE 7.17 The proposed metabolic activation of chloroform. FIGURE 7.17 The proposed...