Physiological Effects

Aspirin. Major analgesic which is responsible for many cases of therapeutic, accidental and intentional poisoning. Metabolized by hydrolysis to salicylic acid which is conjugated. Conjugation pathways are saturable so that the half-life increases with dosage. Therefore blood level of salicylate rises disproportionately with dosage. When salicylate enters tissues, it uncouples oxidative phosphorylation causing: heat generation, increased cellular metabolism and production of carbon dioxide, increased requirement for oxygen, increased rate and depth of breathing via the effect on central respiratory control. This leads to metabolic alkalosis and overcompensation leads to metabolic acidosis. Acidosis allows more non-ionized salicylate to enter tissues including CNS, leading to more metabolic effects and greater acidosis and decreased urinary excretion. Effects on CNS may lead to death. Treatment involves alkaline diuresis, reduction of temperature, replacement of ions and glucose.

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Your Metabolism - What You Need To Know

Your Metabolism - What You Need To Know

If you have heard about metabolism, chances are it is in relation to weight loss. Metabolism is bigger than weight loss, though, as you will learn later on. It is about a healthier, better you. If you want to fire up your metabolism and do not have any idea how to do it, you have come to the right place. If you have tried to speed up your metabolism before but do not see visible results, you have also come to the right place.

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