Anatoly F Vanin1 and Eugenia B Manukhina2

1Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, 119991,

Russian Federation

2Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow

As widely accepted now, dinitrosyl-iron complexes with thiol-containing ligands {(RS-)2Fe+(NO+)2}+ (DNICs) as well as S-nitrosothiols (RS—NO) can be generated via the L-arginine-dependent pathway ensuring storage and transfer of NO molecules in cells and tissues [1-14]. Moreover, due to the quasi-equilibrium between DNIC and its constituents (Scheme 1):

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