Conclusions

We have demonstrated that NO mediates the efflux of Fe and GSH from cells by an active mechanism mediated by the GSH transporter, MRP1 [89]. The ability of the cell to actively transport and traffic NO overcomes the random process of diffusion that would be inefficient and non-targeted. Hence, our results are relevant to NO transport, intra- and extra-cellular NO-signaling, NO-mediated apoptosis and the cytotoxicity of activated macrophages that is due, in part, to Fe release from tumor cell targets.

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