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Fig. 11. Cells hyper-expressing MRP1 (MCF7-VP) are more sensitive than MCF7-WT cells to the antiproliferative effects of SperNO and this is potentiated by GSH depletion using BSO. Cells were preincubated with media alone or media containing BSO (0.1 mM), for 20 h at 37°C. The cells were then incubated in the presence of SperNO for 24 h at 37°C. Horizontal broken lines indicate the concentration that inhibits proliferation by 50% (IC50) and 90% (IC90). Results are means of 4 experiments. (Taken with permission from Ref. [89].)

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