Nitric Oxide activity in blood and tissue can be preserved for much longer than originally believed over the formation of SNOHb, NOHb, RXNO, nitrite, and free NO. The sum of all these, the NO pool can be characterized and offers an important diagnostic and therapeutic tool. Together with the discovery that nitrite can be recycled into bioactive NO again in vivo, these new insights may stimulate the development of new approaches in the diagnosis and treatment of NO deficiency states inherent to many vascular diseases. This may help closing the gap between bench and bedside.

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