Therapeutic Uses Of Lmw Nitrosothiols

Hitherto, therapeutic application of LMW nitrosothiols was limited because they elicit a rapid and strong vasodilatory response which exceeds the margins of safety for humans. In short, they are too effective as vasodilators. Alternative donors like organic nitrates or nitroglycerine are considered safer for clinical applications as they provide better control over the vasodilation. These alternative NO donors are described in detail in Chapter 17 of this book. The risk of excessive hypotension makes that clinical studies of the effect of GSNO in humans are very few. A clinical study into the effects of infusion of GSNO into the bloodstream of pregnant women with severe preeclampsia [134] has shown promising improvement in maternal blood pressure (Fig. 9) and uterine arterial resistance (Table 3).

0 50 100 250

0 0

Post a comment