Antidepressants

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a. SSRIs and tricyclic antidepressants are widely used to treat anxiety disorders. SSRIs appear to have similar efficacy to venlafaxine and should also be considered as first line therapy. Their onset of action is much slower than that of the benzodiazepines, but they have no addictive potential and may be more effective. An antidepressant is the agent of choice when depression is present in addition to anxiety.

b. Antidepressants are especially useful in patients with mixed symptoms of anxiety and depression.

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