a. Buspirone is a first-line treatment of GAD. Buspirone usually requires 3-6 weeks at a dosage of 10-20 mg tid for efficacy. It lacks sedative effects. Tolerance to the beneficial effects of buspirone does not seem to develop. There is no physiologic dependence or withdrawal syndrome.
b. Combined benzodiazepine-buspirone therapy may be used for generalized anxiety disorder, with subsequent tapering of the benzodiazepine after 2-4 weeks.
c. Patients who have been previously treated with benzodiazepines or who have a history of substance abuse have a decreased response to buspirone.
d. Buspirone may have some antidepressant effects.
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