Drug Induced Parkinsonian Syndrome

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a. Patients with Parkinsonian syndrome secondary to neuroleptics present with cogwheel rigidity, mask-like facies, bradykinesia, and shuffling gait. This is similar to patients with idiopathic Parkinson's disease.

b. Drug-induced Parkinsonism is treated by adding an anticholinergic agent such as benztropine (Cogentin) or trihexyphenidyl (Artane).

c. The dopamine releasing agent, amantadine, is also effective.

d. Parkinsonian symptoms may also improve with a lower dose of neuroleptic or after switching to a low-potency agent such as thioridazine.

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