1. Since gabapentin is excreted unchanged renally, the only essential pre-treatment evaluation is renal function. However, impaired renal function is not a contraindication to taking gabapentin but merely an indication that the patient will require lower doses.
2. Starting dose is typically 300 mg q day with titration up to an average daily dose of 900-1800 mg q day in divided doses. Some studies have used up to 3600 mg/day. Given its short half-life, time between doses should not exceed 12 hours. Serum levels are not clinically relevant as no therapeutic window has been established.
3. Therapeutic effects can be seen in 2-4 weeks.
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