Treatment Guidelines

1. Valproate usually requires two weeks to take full effect, but a trial of four to six weeks should be completed before evaluating efficacy.

2. Serum levels, along with a CBC, platelet count, and PT/PTT should be obtained weekly during the first month of treatment and steady state levels are approximated in 2-3 days.

3. Divalproex (Depakote) is the best tolerated form of valproate and is often begun at a dosage of 20 • g/kg for rapid stabilization of mania. This roughly corresponds to 500 mg tid or 750 bid with titration up to a serum level of 50-125 mg/mL. The average dose is between 1500-3000 mg/day. Depakote ER (extended release) tablets (500 mg) allow for once a day dosing. Depakote ER has 80-90% bioavailability compared to Depakote.

4. Elderly patients require doses approximately half that of younger adults.

Was this article helpful?

0 0
Anxiety and Depression 101

Anxiety and Depression 101

Everything you ever wanted to know about. We have been discussing depression and anxiety and how different information that is out on the market only seems to target one particular cure for these two common conditions that seem to walk hand in hand.

Get My Free Ebook

Post a comment