1. Bupropion is appropriate for patients who have been unsuccessful using nicotine replacement. Bupropion reduces withdrawal symptoms and can be used in conjunction with nicotine replacement therapy. The treatment is associated with reduced weight gain. Bupropion is contraindicated with a history of seizures, anorexia, heavy alcohol use, or head trauma.
2. Bupropion is started at a dose of 150 mg daily for 3 days and then increased to 300 mg daily for 2 weeks before the patient stops smoking. Bupropion is then continued for 3 months. When a nicotine patch is added to this regimen, the abstinence rates increase to 50% compared with 32% when only the patch is used.
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Among the evils which a vitiated appetite has fastened upon mankind, those that arise from the use of Tobacco hold a prominent place, and call loudly for reform. We pity the poor Chinese, who stupifies body and mind with opium, and the wretched Hindoo, who is under a similar slavery to his favorite plant, the Betel but we present the humiliating spectacle of an enlightened and christian nation, wasting annually more than twenty-five millions of dollars, and destroying the health and the lives of thousands, by a practice not at all less degrading than that of the Chinese or Hindoo.