N Photosensitivity

1. Antipsychotic agents often cause photosensitivity and a predisposition to sunburn.

2. Photosensitivity is especially common with low-potency agents such as chlorpromazine. Patients should be advised to use sunscreen.

O. Cholestatic jaundice is a rare hypersensitivity reaction that is most common with chlorpromazine. Cholestatic jaundice is usually reversible after discontinuation of the medication. Most cases develop during the third and fourth weeks of treatment. Treatment should include switching to another class of antipsychotic drug after a drug-free interval.

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