a. SSRIs include fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), fluvoxamine (Luvox) and citalopram (Celexa).
b. SSRIs are commonly used as first-line agents as well as secondary choices for depression that does not respond to tricyclics.
c. SSRIs, with their comparatively benign side-effect profile, allow once daily dosing and present less danger from overdose because they lack the cardiovascular toxicity of the tricyclics.
d. Another advantage of SSRIs is that they require less dosage titration. Thus, a therapeutic dose may be achieved earlier than with tricyclics.
e. Although many patients take SSRIswith no adverse consequences, the most frequent side effects are insomnia, GI upset, agitation, and sexual dysfunction.
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