Antipsychotic Side Effects

A. Low-potency agents such as chlorpromazine produce a higher incidence of anticholinergic side effects, sedation and orthostatic hypotension compared to high-potency agents such as haloperidol.

B. High-potency agents such as haloperidol and fluphenazine produce a high incidence of extrapyramidal symptoms such as acute dystonic reactions, Parkinsonian syndrome, and akathisia.

C. Moderate-potency agents include trifluoperazine and thiothixene, and have side effect profiles in between the low- and high-potency agents.

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