a. Venlafaxine is the first line treatment for GAD. Effexor XR can be started at 75 mg per day; however, patients with severe anxiety or panic attacks should be started at 37.5 mg per day. The dose should then be titrated up to a maximum dosage of 225 mg of Effexor XR per day.
b. Venlafaxine usually requires several weeks to achieve efficacy and an adequate trial should last for 4-6 weeks.
c. The side effect profile for GAD patients is similar to that seen with depressive disorders.
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