A. Clozapine (Clozaril) is a dibenzodiazepine derivative and is considered an atypical antipsychotic agent.
1. Clozapine is used for the treatment of patients who have not responded to, or who cannot tolerate, other neuroleptics.
2. Clozapine is associated with a 1 % incidence of agranulocytosis, which can be fatal. New guidelines are expected to recommend monitoring of WBC weekly for the first six months of treatment and every two weeks thereafter. When white blood cell counts drop below 3 x 1012/liter, clozapine must be discontinued.
3. Eosinophilia (>4000/mm3) may be a precursor of leukopenia. Clozapine should be interrupted until count is below 3000mm3.
4. Clozapine is unique in that it does not produce extrapyramidal symptoms or tardive dyskinesia.
5. Seizures are especially common at dosages above 600 mg per day.
7. There is no significant elevation of prolactin or subsequent side effects.
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With all the stresses and strains of modern living, panic attacks are become a common problem for many people. Panic attacks occur when the pressure we are living under starts to creep up and overwhelm us. Often it's a result of running on the treadmill of life and forgetting to watch the signs and symptoms of the effects of excessive stress on our bodies. Thankfully panic attacks are very treatable. Often it is just a matter of learning to recognize the symptoms and learn simple but effective techniques that help you release yourself from the crippling effects a panic attack can bring.