A. Clozapine (Clozaril) is a dibenzodiazepine derivative and is considered an atypical antipsychotic agent.
1. Clozapine is used for the treatment of patients who have not responded to, or who cannot tolerate, other neuroleptics.
2. Clozapine is associated with a 1 % incidence of agranulocytosis, which can be fatal. New guidelines are expected to recommend monitoring of WBC weekly for the first six months of treatment and every two weeks thereafter. When white blood cell counts drop below 3 x 1012/liter, clozapine must be discontinued.
3. Eosinophilia (>4000/mm3) may be a precursor of leukopenia. Clozapine should be interrupted until count is below 3000mm3.
4. Clozapine is unique in that it does not produce extrapyramidal symptoms or tardive dyskinesia.
5. Seizures are especially common at dosages above 600 mg per day.
7. There is no significant elevation of prolactin or subsequent side effects.
Was this article helpful?
This guide Don't Panic has tips and additional information on what you should do when you are experiencing an anxiety or panic attack. With so much going on in the world today with taking care of your family, working full time, dealing with office politics and other things, you could experience a serious meltdown. All of these things could at one point cause you to stress out and snap.