A. Lamotrigine is a relatively new anticonvulsant. A small number of controlled studies support its effectiveness in mood disorders.
B. Clinical experience suggests that it may be effective in the treatment of manic and depressive episodes. It also appears to be more effective in the treatment of depression compared to other mood stabilizers, prompting some clinicians to use it in treatment resistant unipolar depression.
C. Lamotrigine has been successful as monotherapy and as adjunctive treatment to other mood stabilizers and/or antidepressants. It appears to be effective for mixed episodes and rapid cycling.
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