A. Older antidepressants (imipramine, amitriptyline, and MAO inhibitors) are moderately effective, especially for symptoms of increased arousal, intrusive thoughts, and coexisting depression. Sertraline (Zoloft) has demonstrated efficacy for all the symptom clusters of PTSD. Other SSRIs are also likely to be effective. Treatment at higher doses than are used for depression may be required.
B. Propranolol, lithium, anticonvulsants, and buspirone may be effective and should be considered if there is no response to antidepressants. Benzodiazepines have not been effective for PTSD, except during the early, acute phase of the illness.
C. Psychotherapy, behavioral therapy, support groups, and family therapy are effective adjuncts to pharmacological treatment.
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