Cellbased Assays

A more direct method of screening compounds for cellular activity, while simultaneously determining that the compound can access the receptor or enzyme in its cellular environment, is by assaying the effects of drugs on whole cells. This type of assay will eliminate at least one step in the process of drug screening, since all drugs will eventually have to be tested with whole cells. However, because there are multiple cellular systems that could be affected, it becomes more difficult to define a mechanism of action for a compound discovered using a cell-based assay.

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