Pharmaceutical medicine is a relatively new, but rapidly growing, academic discipline in the USA. The American Academy of Pharmaceutical Physicians (AAPP) was founded in 1993 and hosted, in 1999, a meeting of the International Federation of Associations of Pharmaceutical Physicians (IFAPP). The birth of AAPP coincided with many ongoing changes in the pharmaceutical industry in the USA, as health care delivery began to move more towards managed care, and large corporations began to amalgamate and downsize. As these trends continue into the 21st century, pharmaceutical physicians are increasingly regarding consultancy work and contract research organization (CRO) affiliation as good career opportunities, and now recognize the need for continuing education and training in this broad spectrum discipline.

This textbook, which represents a collaborative effort of international experts, is dedicated to the more than 3,500 pharmaceutical physicians and all the other professionals working in the US pharmaceutical industry and allied fields. It is also intended to be useful for those outside the USA because the basic tenets of the specialty have, for a long time, become global.

As editors, we would like to thank our contributors for their expertise, their dedication, and their vision. We would like to thank and acknowledge the work and counsel of our colleague Robert Bell, MD, MRPharmS, who helped us greatly during the early part of this project. We would also like to thank and acknowledge the enormous help, encouragement, and patience of the team at John Wiley & Sons, Inc., UK, with whom we have worked closely over these past few years, among whom we have particularly stressed (!) Michael Davis, Deborah Reece, Hannah Bradley, Lewis Derrick, and Hilary Rowe.

Lastly, we would like to thank our families, and friends, who have withstood the frequent telephone calls, e-mails, and meetings, often late into the night. Indeed, to all who made this project possible, both authors and non-authors, we thank you. We are certain that this specialty, and our patients, even though we may help them vicariously, will benefit because of your contributions.

Andrew Fletcher Lionel Edwards Tony Fox Peter Stonier

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