Section VIII Business Aspects

40 Outsourcing Clinical Drug Development Activities to Contract Research Organizations (CROs):

Critical Success Factors 461

John R. Vogel

41 The Third World 483

Gamal Hammad

42 Financial Aspects of Clinical Trials 501

R. Graham Hughes and N. Turner

43 The Impact of Managed Care on the US Pharmaceutical Industry 513

Robert Chaponis, Christine Hanson-Divers and Marilyn J. Wells

Appendix—Useful Internet Links 529

Index 531

39 The Multinational Corporations: Cultural Challenges, the Legal/Regulatory Framework and the Medico-commercial Environment 453

R. Drucker and R. Graham Hughes

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