Transdermal vs Topical

The principal distinction between transdermal and topical drugs is that only the former are intended for systemic delivery. Both formulations are, however, subject to the same skin irritancy testing prior to human exposures.

The skin is biologically intended to be a barrier. Evading this barrier is not easy, because drugs must traverse dead epithelium and live dermis; the former is hydrophobic, while lipophilic drugs tends to form a reservoir in the latter. As in oral transmucosal administration, potent drugs, with modest requirements for mass absorbed and reasonable lipophilicity, are the best candidates for transdermal delivery. Fentanyl, nicotine, and sco-polamine are good examples.

The Smoker's Sanctuary

The Smoker's Sanctuary

Save Your Lungs And Never Have To Spend A Single Cent Of Ciggies Ever Again. According to a recent report from the U.S. government. Centers for Disease Control and Prevention, more than twenty percent of male and female adults in the U.S. smoke cigarettes, while more than eighty percent of them light up a cigarette daily.

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