Hypersensitivity Reaction Carcinggenesis Teratggenesis

FIGURE 16.4 General scheme for the role played by reactive drug metabolites in causing a variety of adverse reactions. The reactive metabolites usually account for only a small fraction of total drug metabolism and are too unstable to be chemically isolated and analyzed. In many cases, covalent binding of these metabolites to tissue macromolecules only occurs after their formation exceeds a critical threshold that overcomes host detoxification and repair mechanisms.

variability in incidence of these reactions reflects varying activity in the parallel pathways involved in metabolizing drugs to either nontoxic or reactive metabolites. In some cases, it has been possible to actually relate the risk of an adverse drug reaction to polymorphic drug-metabolizing phenotype.

Coping with Asthma

Coping with Asthma

If you suffer with asthma, you will no doubt be familiar with the uncomfortable sensations as your bronchial tubes begin to narrow and your muscles around them start to tighten. A sticky mucus known as phlegm begins to produce and increase within your bronchial tubes and you begin to wheeze, cough and struggle to breathe.

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