Introduction 449

Components of Preclinical Drug Development 450

In Vitro Studies 450

Drug Supply and Formulation 451

In Vivo Studies — Efficacy Testing in Animal

Models 452 In Vivo Studies — Preclinical Pharmacokinetic and

Pharmacodynamic Testing 455 In Vivo Studies — Preclinical Toxicology 455

Drug Development Programs at the NCI 456 History 456

The 3-Cell-Line Prescreen and 60-Cell-Line Screen 456

NCI Drug Development Process 459

The Challenge — Molecularly Targeted

Therapies and New Paradigms for Clinical Trials 459

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Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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