Kefauver-Harris Drug Amendments, 504
Ketoconazole-terfenadine interaction, 235
Kety, Seymour, 26n Khakoo, S., 490 Khor, S. Pl, 468 Kidney, artificial, 57-59, 58/ Kinetic homogenity, 95 Kinetics. See also Pharmacokinetics bioavailability after oral administration, 42-44, 43// case studies chemopallidectomy, Parkinson's disease, 124-126 chemotherapeutic agents, ovarian cancer, 111-114 cytosine arabinoside, JC virus infection, 113-114 central issues, 107-108
Kinetics (continued) continuous renal replacement therapy clearance by continuous hemodialysis, 64 clearance by continuous hemofiltration, 63-64 extracorporeal clearance, 64-65 definition, 88 delivery across a planar-tissue interface general principles, 108-114 small molecules vs. macromolecules, 114-117 from a point source high-flow microinfusion case, 118-126 low-flow microinfusion case,
117-118 overview, 117 first-order elimination, 16-17 homogenity, definition, 95 insulin distribution, 26, 26/ intermittent hemodialysis factors affecting hemodialysis, 60-63
solute transfer across dialyzing membranes, 57-59, 58// link to mathematics, 88-89 Michaelis-Menten, 15-16, 38, 67 NAPA absorption, 40/ noncompartmental model parameters, 93-95 overview, 107 Koecheler, J. A., 412 Kolff, W. J., 57
Kolff-Brigham artificial kidney,
58, 58/ Kosowski, B. D., 261 Kramer, K. J., 302 Kupffer cells, 257
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All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.