In Prostate Cancer Families With Aggressive Disease

To examine the hypothesis that the tendency to develop aggressive prostate cancer may have an inherited component, and that linkage analysis of an appropriately chosen subset of prostate cancer families could be used to map the genes responsible, the ICPCG recently carried out a genome-wide linkage scan on pedigrees that had at least three men with clinically aggressive prostate cancer as defined by high-grade and/or non-organ-confined disease (64). Pedigrees of this type are rareā€”of 1233 prostate cancer pedigrees, 166 (13%) met these criteria, making such a study possible only by pooling data from multiple family collections. Among the 166 pedigrees with aggressive prostate cancer, the strongest linkage signals were on chromosome 6p (LOD = 3.0), chromosome 11q (LOD = 2.4), and chromosome 20q (LOD = 2.5). For chromosome 11, the linkage signal was largest among pedigrees with an average at diagnosis of 65 years or younger. The results from the analysis of this unique collection of families implicate several loci as harboring genes that may predispose men to develop aggressive prostate cancer, and provide a basis for identification of such genes.

Table 1

Summary of Genome-Wide Scan Linkage Data from 1233 Prostate Cancer Families''

1-LOD drop interval

Table 1

Summary of Genome-Wide Scan Linkage Data from 1233 Prostate Cancer Families''

1-LOD drop interval

Characteristics

Region

cM

Nearest marker

Analysis

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