Prostate Androgen Receptor383

Chun-Te Wu, Shuyuan Yeh, Qingquan Xu, Zhiming Yang, Philip Chang, Yueh-Chiang Hu and Chawnshang Chang

Introduction 383 Generation of Androgen Receptor Knockout (ARKO) Mice 384 Prostate Development and Carcinogenesis in

Prostate-Specific ARKO Mice 385 TRAMP Mice Lacking the Endogenous AR but Carrying the T877A Mutated Transgene 386 ARKO Mice with AR-97Q and AR-24Q

Transgene Expression 387

Inducible ARKO and ARKO TRAMP Mice 387

ARKO Human Prostate Cancer CWR22R Cells 388

Conclusion 390

References 390

17 Capturing Signal Anomalies of Human Prostate

Cancer into Mouse Models 393

Hong Wu, Ani Khodavirdi and Pradip Roy-Burman

Introduction 393

Cell Surface Signaling Molecules 395

Intracellular Signaling Molecules 400

Collaboration Between Signaling Molecules 408

Summary and Conclusions 410

Acknowledgments 411

References 412

Index 423

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