Nonbiofouling Surfaces Generated from Phosphorylcholine Bearing Polymers

Yasuhiko Iwasaki, Nobuo Nakabayashi, Kazuhiko Ishihara

Abstract. The preparation and characterization of nonbiofouling surfaces generated from phosphorylcholine (PC)-bearing polymers are described. It is proposed that PC groups are an optimum surface with which to create biointerfaces because the surfaces have similarities with biomembranes. Nonspecific protein adsorption is generally the first process to occur when polymers come into contact with the vital environment, and this induces unfavorable bioreactions. Due to the properties of PC surfaces, such as high hydrophilicity, water structure, and zero ^-potential, protein adsorption is effectively reduced on the PC-bearing surface. This surface property may be important for biomedical applications. The well-defined design of PC surfaces is also introduced in this chapter. These surfaces may be micro-or nanofabricated for, for example, medical devices and sensors. Control of cell-material interactions is effective on PC-bearing surfaces due to the negligible nonspecific interactions.

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