On a Phosphorylcholine Polymer Nonfouling Surface

Cell adhesion on material surfaces depends strongly on the plasma (serum) protein adsorption onto the surface because there are many kinds of cell adhesive proteins in plasma (serum). It has already been reported that an MPC polymer can reduce the adhesion of a variety of cells such as blood cells (Hasegawa et al. 2002; Ishihara et al. 1992, 1993, 2000; Iwasaki et al. 1997, 2001), fibroblasts (Ishihara et al. 1999; Iwasaki et al. 1999), and

Phosphorylcholine Polymer
Fig. 14. a Synthetic route of poly(MPC) brushes on silicon wafer via atom transfer radical polymerization. b Thickness of silicon-sputtered poly(MPC) brushes as function of polymerization time

bacteria (Hirota et al. 2005; Patel et al. 2005). By manipulation of the surface distribution of MPC polymers or tag-immobilization to recognize a cell on MPC polymers, the cell attachment on the surface will be well controlled.

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