Ling-Shu Wan, Zhi-Kang Xu, Xiao-Jun Huang
Abstract. Protein adsorption and/or deposition at the surface of polymeric membranes play important roles in membrane separation processes. Although polyacrylonitrile-based membranes have been used successfully in many fields, surface modifications to improve the protein resistance and hemocompatibility have received considerable interest. Various methods such as copolymerization, grafting, physical adsorption, biomacro-molecule immobilization, and biomimetic modification, have been explored to build a friendly microenvironment for proteins, especially enzymes, at the membrane surface. Herein, the behaviors of proteins at the surfaces of polyacrylonitrile-based membranes are reviewed.
Polyacrylonitrile (PAN) exhibits good thermal stability, mechanical strength, and membrane formation properties, and microporous PAN membranes are commercially available. However, its relatively poor hy-drophilicity and biocompatibility hinder this type of membrane in further applications. Just like other ultrafiltration membranes, PAN-based membranes face an unavoidable problem with regard to their applications: a progressive decline in flux and a change of membrane selectivity. This phenomenon, more commonly known as membrane fouling, is attributed mainly to concentration polarization and protein fouling. Protein fouling, including adsorption/deposition on the membrane surface and pore blockage, generally results in a largely irreversible decline of flux. Many researchers have therefore provided important insights into the effects of interactions between proteins and membranes or between proteins. On the other hand, PAN-based membranes have also been used as blood-contacting materials in hemodialysis, plasmapheresis, plasma fractiona-tion, leukofiltration, and artificial livers (Krasteva et al. 2002; Sun et al.
Ling-Shu Wan, Zhi-Kang Xu, Xiao-Jun Huang: Institute of Polymer Science, Zhejiang University, Hangzhou 310027, People's Republic of China, E-mail: [email protected]
Principles and Practice Proteins at Solid-Liquid Interfaces Philippe Dejardin (Ed.) © Springer-Verlag Berlin Heidelberg 2006
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