Kidney Function Restoration Program

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Modulation of the Adsorption and Activity of Protein/Enzyme on the Polypropylene Microporous Membrane Surface by Surface Modification

Qian Yang, Zhi-Kang Xu, Zheng-Wei Dai

Abstract. As an excellent membrane material, polypropylene microporous membrane (PPMM), has received much consideration in recent years. PPMM has also been used widely in many fields such as water treatment, enzyme immobilization, and blood oxygenation. However, poor surface properties cumber the further applications of this material. Many efforts have been made to solve this problem, and surface modification seems to be the most efficient way. In this article we introduce some work in which surface modification was conducted to reduce nonspecific protein adsorption and to modulate the activity of immobilized enzymes on the PPMM surface. We focus on the studies of our group, although other researches are also discussed.

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